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KMID : 1149120200170020054
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Journal of the Korean Society for Psoriasis
2020 Volume.17 No. 2 p.54 ~ p.57
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Hepatitis B reactivation During Adalimumab Treatment in a Patient with Psoriasis
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Choi Go-Woon
Shin Jung-U
Lee Hee-Jung
Yoon Moon-Soo
Kim Dong-Hyun
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Abstract
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Adalimumab, tumor necrosis factor-alpha inhibitor, has been used for the treatment of various immune-mediated inflammatory diseases including psoriasis. However, it may cause hepatitis B virus (HBV) reactivation. A 64 years-old male patient presented with plaque psoriasis for 15 years’ duration. After receiving phototherapy and oral methotrexate for 6 months, adalimumab treatment was started due to inefficacy. He has been regularly follow-up at the local clinic as a chronic HBV carrier. Before adalimumab treatment, HBV DNA level was 1.15×102 IU/ml. However, the level gradually increased to 2.07×104 IU/ml at 6 months and 2.02×105 IU/ml at 12 months of treatment. Adalimumab was discontinued and he was referred to a hepatologist. He was identified as an HBV inactive carrier, and has been observed with 6-month follow-up. This case report highlights the importance of screening and preventing HBV reactivation in patients using immunosuppressive drugs.
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KEYWORD
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Adalimumab, Hepatitis B virus, Psoriasis
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